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Dr. Jean Chen

Dr. Jean Chen

Canada Research Chair in Neuroimaging of Aging

Scientist, Rotman Research Institute

Associate Professor, Medical Biophysics, University of Toronto

(416) 785-2500 x2017

Research Focus


Normal brain function is predicated upon continuous neuronal and vascular interplays, a mechanism that is essential to brain function. It is also likely to deteriorate during the cognitive decline associated with aging as well as neurological disorders. Despite previous research efforts, the causes of aging-related illnesses such as dementia remain unclear, and the key to preventative treatment elusive. My research is driven by the need to better understand disease mechanisms, by using neuroimaging to observe the living brain. My research is focused on functional magnetic resonance imaging (fMRI) methodological development, physiological modeling, and the application of our methods in characterizing diseases/treatments. Specifically, we are interested in:

  • Functional MRI methodological development

  • Measurement of cerebral perfusion and metabolism using MRI techniques

  • Measurement of tissue microstructure using diffusion-weighted MRI

Investigating the relationship between functional and structural brain changes in neurodegenerative diseases

Research Technologies